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J Cell Biol. 2005 Dec 19;171(6):939-45.

Tricellulin constitutes a novel barrier at tricellular contacts of epithelial cells.

Author information

1
Department of Cell Biology, Faculty of Medicine, Kyoto University, Sakyo-ku, Kyoto 606-8501, Japan.

Abstract

For epithelia to function as barriers, the intercellular space must be sealed. Sealing two adjacent cells at bicellular tight junctions (bTJs) is well described with the discovery of the claudins. Yet, there are still barrier weak points at tricellular contacts, where three cells join together. In this study, we identify tricellulin, the first integral membrane protein that is concentrated at the vertically oriented TJ strands of tricellular contacts. When tricellulin expression was suppressed with RNA interference, the epithelial barrier was compromised, and tricellular contacts and bTJs were disorganized. These findings indicate the critical function of tricellulin for formation of the epithelial barrier.

PMID:
16365161
PMCID:
PMC2171318
DOI:
10.1083/jcb.200510043
[Indexed for MEDLINE]
Free PMC Article

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