Format

Send to

Choose Destination
J Exp Med. 2005 Dec 19;202(12):1617-21.

Tuberculosis in children and adults: two distinct genetic diseases.

Author information

1
Laboratory of Human Genetics of Infectious Diseases, University of Paris René Descartes-INSERM U550, Necker Medical School, 75015 Paris, France.

Abstract

Disseminated disease in children and pulmonary disease in adults constitute two major epidemiological and clinical forms of tuberculosis. Paradoxically, only a small fraction of infected individuals develop clinical tuberculosis, typically one form of the disease or the other. Mendelian and complex genetic predispositions to tuberculosis were reported recently in children and adults, respectively. Here, we argue that tuberculosis and its clinical expression largely reflect the underlying human genetic background.

PMID:
16365144
PMCID:
PMC2212964
DOI:
10.1084/jem.20052302
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for HighWire Icon for PubMed Central
Loading ...
Support Center