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Neuron. 2005 Dec 22;48(6):881-4.

Key regulators in neuronal polarity.

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1
Department of Cell Pharmacology, Nagoya University Graduate School of Medicine, Nagoya, Aichi 466-8550, Japan.

Abstract

Neurons are highly polarized cells, most of which develop a single axon and several dendrites. These two compartments acquire specific characteristics that enable neurons to transmit intercellular signals from several dendrites to an axon. A wealth of recent studies has shown that PI 3-kinase, Rho family GTPases, the Par complex, and cytoskeleton-related proteins participate in the initial events of neuronal polarization. Here, we review the role of polarity-regulating molecules and the potential mechanisms underlying the specification of an axon and dendrites.

PMID:
16364893
DOI:
10.1016/j.neuron.2005.11.007
[Indexed for MEDLINE]
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