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Bioorg Med Chem Lett. 2006 May 1;16(9):2352-6. Epub 2005 Dec 20.

Aza-retinoids as novel retinoid X receptor-specific agonists.

Author information

1
Ligand Pharmaceuticals Inc., 10255 Science Center Drive, San Diego, CA 92121, USA. luc_farmer@vrtx.com

Abstract

A new structurally simple series of potent lipophilic aza-retinoids RXR agonists has been developed. SAR studies for the N-alkyl-azadienoic acids described here demonstrate that the RXR activity profile is sensitive to the N-alkyl chain length. Further, we have expanded the work to include azadienoic acids, which exhibited many accessible conformations leading to a better understanding of the SAR around the series.

PMID:
16364638
DOI:
10.1016/j.bmcl.2005.12.003
[Indexed for MEDLINE]

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