Format

Send to

Choose Destination
Respir Med. 2006 Jul;100(7):1202-7. Epub 2005 Dec 20.

Does Helicobacter pylori have a pathogenic role in bronchiectasis?

Author information

1
Servei de Pneumologia, Hospital Clínic, Institut d'lnvestigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Universitat de Barcelona (UB), Villarroel 170, 08036 Barcelona, Spain. jangrill@clinic.ub.es

Abstract

AIM:

To investigate the presence of Helicobacter pylori (H. pylori) in bronchial biopsies of patients with bronchiectasis, by histochemical and immunochemical staining.

SETTING:

800-bed tertiary university hospital.

METHODS:

Observational study.

PATIENTS:

forty-six patients with bronchiectasis in a stable clinical condition and 8 control patients.

INTERVENTIONS:

Serum samples determination of IgG levels for H. pylori by ELISA. Immunostaining with an anti-H. pylori antibody (NCL-HPp, Novocastra) of bronchial mucosa obtained by fiberoptic bronchoscopy from both patients with bronchiectasis and controls.

RESULTS:

Twenty-one out of 46 patients with bronchiectasis (46%) had positive serology for H. pylori. We obtained 40 bronchial biopsies in patients with bronchiectasis and 8 bronchial biopsies in control patients. No evidence of H. pylori was obtained in the bronchial samples of both patients and controls.

CONCLUSIONS:

The results of our study could not demonstrate the presence of H. pylori in bronchial specimens from patients with bronchiectasis.

PMID:
16364621
DOI:
10.1016/j.rmed.2005.10.021
[Indexed for MEDLINE]
Free full text

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center