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Res Microbiol. 2006 Mar;157(2):93-8. Epub 2005 Nov 9.

Surviving inside a macrophage: the many ways of Brucella.

Author information

  • 1Laboratory of Intracellular Parasites, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 903 South 4th Street, Hamilton MT 59840, USA. jcelli@niaid.nih.gov

Abstract

Bacteria of the genus Brucella are intracellular pathogens capable of survival and replication within macrophages of mammalian hosts. Recent advances have shed light on virulence factors and host functions involved at various stages of the Brucella intracellular life cycle. This review focuses on how this pathogen uses multiple strategies to circumvent macrophage defense mechanisms and generate an organelle permissive for replication.

PMID:
16364608
DOI:
10.1016/j.resmic.2005.10.002
[PubMed - indexed for MEDLINE]

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