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J Headache Pain. 2005 Sep;6(4):185-7.

Association between migraine and HLA-DRB1 gene polymorphisms.

Author information

1
Neurology III-Headache Center, Department of Neuroscience, University of Turin, Via Cherasco 15, I-10126, Turin, Italy. irainero@molinette.piemonte.it

Abstract

We examined the distribution of HLA-DRB1 alleles in a cohort of 255 Italian migraine patients and in a control group of 325 healthy subjects. The frequency of DRB1*12 allele was found to be significantly reduced (p=0.02) in patients with migraine while the DRB1*16 allele was significantly increased (p=0.04) in comparison with controls. When the patients were divided into disease subgroups (migraine with and without aura), HLA-DRB1**16 allele was significantly increased (p<0.05) only in migraine without aura patients. We conclude that, in Italian patients, migraine is associated with different alleles of the HLA-DRB1 locus. Our data suggest the presence of a genetic susceptibility factor for migraine within the HLA region.

PMID:
16362659
PMCID:
PMC3452004
DOI:
10.1007/s10194-005-0180-3
[Indexed for MEDLINE]
Free PMC Article

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