D2-40 staining in sinonasal-type hemangiopericytoma--further evidence of distinction from conventional hemangiopericytoma and solitary fibrous tumor

Virchows Arch. 2006 Apr;448(4):459-62. doi: 10.1007/s00428-005-0130-0. Epub 2005 Dec 16.

Abstract

D2-40 is a monoclonal antibody, which reacts with a fixative-resistant epitope of lymphatic endothelium. Sinonasal-type hemangiopericytoma (SHP) and tumors of the (conventional) hemangiopericytoma/solitary fibrous tumor family (HP/SFT) are characterized by prominent vasculature. However, data concerning D2-40 labeling of these tumors are very sparse. In the present study, we investigated D2-40 staining in tissue specimens of 17 patients with SHP (male to female ratio of 2.4:1, median age of 63 years) and compared the immunolabeling with 20 cases of HP/SFT, including three SFT cases from nasal mucosa. D2-40 was detected in vascular channels of all SHP patients examined. By contrast, all cases of HP/SFT did not reveal any vascular channel being positive for D2-40, neither in the nasal cases nor in the remaining patients. This study presented for the first time data on D2-40 labeling in a series of SHP, HP/SFT, and supports the distinction of SHP from HP/SFT.

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Antibodies, Monoclonal / immunology*
  • Antibodies, Monoclonal, Murine-Derived
  • Biomarkers, Tumor / analysis
  • Child
  • Diagnosis, Differential
  • Female
  • Fibroma / chemistry
  • Fibroma / pathology*
  • Hemangiopericytoma / chemistry
  • Hemangiopericytoma / pathology*
  • Humans
  • Male
  • Middle Aged
  • Paranasal Sinus Neoplasms / chemistry
  • Paranasal Sinus Neoplasms / pathology*
  • Soft Tissue Neoplasms / chemistry
  • Soft Tissue Neoplasms / pathology*

Substances

  • Antibodies, Monoclonal
  • Antibodies, Monoclonal, Murine-Derived
  • Biomarkers, Tumor
  • monoclonal antibody D2-40