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Occup Environ Med. 2006 Jan;63(1):39-44.

Occupational risk factors for nasopharyngeal cancer among female textile workers in Shanghai, China.

Author information

1
Program in Epidemiology, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.

Abstract

AIMS:

To investigate whether occupational exposure to dusts and chemicals in the Chinese textile industry are associated with risk of nasopharyngeal cancer.

METHODS:

Sixty seven nasopharyngeal carcinoma (NPC) cases identified during 1989-98 and a random sample (n = 3188) of women were included in a case cohort study nested in a cohort of 267,400 women textile workers in Shanghai, China. A complete occupational history of work in the textile industry was obtained for each woman. A job exposure matrix developed by experienced industrial hygienists was used to assess exposures to specific dusts and chemicals.

RESULTS:

Risk of NPC is associated with cumulative exposure to cotton dust. The hazard ratio for women cumulatively exposed to >143.4 mg/m3 x years of cotton dust was 3.6 (95% CI 1.8 to 7.2) compared with unexposed women. Trends of increasing risk were also found with increasing duration of exposure to acids and caustics (p = 0.05), and with years worked in dyeing processes (p = 0.06). Women who worked at least 10 years in dyeing processes had a 3.6-fold excess risk of NPC (95% CI 1.0 to 12.1).

CONCLUSIONS:

Occupational exposure to cotton dust, acids, and caustics, and work in dyeing and printing jobs in the textile industry may have increased risk of NPC in this cohort.

PMID:
16361404
PMCID:
PMC2078032
DOI:
10.1136/oem.2005.021709
[Indexed for MEDLINE]
Free PMC Article
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