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Curr Opin Pharmacol. 2006 Feb;6(1):82-8. Epub 2005 Dec 19.

Glutamate-based therapeutic approaches: ampakines.

Author information

1
University of California, Department of Psychiatry and Human Behavior, Irvine, California 92617, USA. glynch@uci.edu

Abstract

Ampakines are a structurally diverse family of small molecules that positively modulate alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-type glutamate receptors, and thereby enhance fast, excitatory transmission throughout the brain. Surprisingly, ampakines have discrete effects on brain activity and behavior. Because their excitatory synaptic targets mediate communication between cortical regions, serve as sites of memory encoding, and regulate the production of growth factors, ampakines have a broad range of potential therapeutic applications. Several of these possibilities have been tested with positive results in preclinical models; preliminary clinical work has also been encouraging.

PMID:
16361116
DOI:
10.1016/j.coph.2005.09.005
[Indexed for MEDLINE]
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