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Curr Opin Pharmacol. 2006 Feb;6(1):89-97. Epub 2005 Dec 19.

Kainate receptor physiology.

Author information

1
Instituto de Neurociencias de Alicante, Consejo Superior de Investigaciones Científicas-Universidad Miguel Hernández, 03550, San Juan de Alicante, Spain. jlerma@umh.es

Abstract

Glutamate receptors constitute a complex signalling system at most of the excitatory synapses in the brain. Of the known ionotropic glutamate receptors, kainate receptors are ubiquitous in the central nervous system, and a considerable amount of data indicates that this class of receptors is present at both sides of the synapse. Pre- and postsynaptic kainate receptors are able to regulate both transmission of information and excitability in a synapse-specific manner. Proteins interacting with kainate receptor subunits are being identified and functional studies have provided evidence of the existence of a dual signalling system. It has become clear that these receptors have a role in synaptic plasticity and that they might also have a fundamental role in epilepsy through the strategic control of network excitability. However, the role of kainate receptors in other brain pathologies remains obscure.

PMID:
16361114
DOI:
10.1016/j.coph.2005.08.004
[Indexed for MEDLINE]
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