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Curr Opin Cell Biol. 2006 Feb;18(1):74-8. Epub 2005 Dec 19.

Controlling centrosome number: licenses and blocks.

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Department of Biological Sciences, Stanford University, Stanford, California 94305, USA.


Centrosomes organize microtubule structures in animal cells. The centrosome duplicates once per cell cycle in most dividing cells via a pathway that relies on a pre-existing centrosome. The molecular mechanism of this 'once and only once' control is not understood, and recent results show that centrosomes can also be assembled by a de novo pathway that bypasses this control. These results require a rethinking of how proper centrosome number is maintained. We propose that the engagement of centrioles with each other normally blocks centrosome re-duplication, and that disengagement of centrioles from each other at the end of mitosis licenses them for duplication in the subsequent cell cycle.

[Indexed for MEDLINE]

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