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Surgery. 2005 Dec;138(6):986-93; discussion 993.

Selective arterial chemoembolization for hepatic metastases from medullary thyroid carcinoma.

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1
Department of General, Visceral and Vascular Surgery, Martin-Luther University of Halle-Wittenberg, Germany. kerstin.lorenz@medizin.uni-halle.de

Abstract

BACKGROUND:

Hepatic metastases from medullary thyroid carcinoma (MTC) may impair quality of life by hypercalcitonemia-associated diarrhea and pain. In this prospective study, the effect of selective arterial chemoembolization (SACE) was evaluated.

METHODS:

Eleven patients with hepatic metastases from MTC received 1 to 9 courses of SACE using epirubicine. Symptomatic, biochemical, and morphologic responses on SACE were recorded.

RESULTS:

Symptomatic response was observed in all symptomatic patients. However, biochemical and radiologic response occurred only in 6 patients. Liver function was not affected by SACE. One patient with unexpected concurrent pheochromocytoma metastases died after the first course. Development of side effects in the course was observed in 8 patients but were only World Health Organization grade 1. Patients' satisfaction with SACE was excellent. Long-term follow-up found 7 patients alive (1-72 months). Three patients died with tumor 6, 12, and 24 months after SACE, respectively.

CONCLUSION:

SACE provided good symptom palliation for the majority of patients with hepatic metastases from MTC. However, transient remission or stabilization of hepatic metastases resulted in only 60%. Further studies using a randomized protocol are required.

PMID:
16360382
DOI:
10.1016/j.surg.2005.09.020
[Indexed for MEDLINE]
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