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Theor Popul Biol. 2006 Aug;70(1):56-62. Epub 2005 Dec 19.

Prediction of effects of genetic drift on variance components under a general model of epistasis.

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1
Institute of Evolutionary Biology, University of Edinburgh, Edinburgh EH9 3JT, UK.

Abstract

For a model of diallelic loci with arbitrary epistasis, Barton and Turelli [2004. Effects of genetic drift on variance components under a general model of epistasis. Evolution 58, 2111-2132] gave results for variances among and within replicate lines obtained by inbreeding without selection. Here, we discuss the relation between their population genetic methods and classical quantitative genetic arguments. In particular, we consider the case of no dominance using classical identity by descent arguments, which generalizes their results from two alleles to multiple alleles. To clarify the connections between the alternative methods, we obtain the same results using an intermediate method, which explicitly identifies the statistical effects of sets of loci. We also discuss the effects of population bottlenecks on covariances among relatives.

PMID:
16360188
DOI:
10.1016/j.tpb.2005.10.001
[Indexed for MEDLINE]
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