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Cell. 2005 Dec 16;123(6):980-2.

PIDD: a switch hitter.

Author information

1
Department of Pharmacology, University of Wisconsin-Madison, 1300 University Avenue, Madison, WI 53706, USA.

Abstract

In response to genotoxic stress, the PIDD protein promotes apoptosis downstream of the tumor-suppressor protein p53. In this issue of Cell, Janssens et al. (2005) demonstrate that, in response to such stress, PIDD forms a nuclear complex that enhances sumoylation of NEMO. This modification is important for the activation of the antiapoptotic transcription factor NF-kappaB.

PMID:
16360026
DOI:
10.1016/j.cell.2005.11.025
[Indexed for MEDLINE]
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