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Fertil Steril. 2005 Dec;84(6):1744.

Reversibility of hypogonadotropic hypogonadism in a patient with the juvenile form of hemochromatosis.

Author information

1
Endocrine Department, Hippokrateion Hospital of Athens, Athens, Greece. drangelnick@hotmail.com

Abstract

OBJECTIVE:

To report a case of complete reversibility of hypogonadotropic hypogonadism with intensive venesection treatment in juvenile hemochromatosis.

DESIGN:

Case report.

SETTING:

Endocrine department of Hippocrateion Hospital of Athens.

PATIENT(S):

A 25-year-old man who presented with hypogonadotropic hypogonadism and severe iron overload due to juvenile hemochromatosis and who was initially treated with phlebotomies and androgen substitution.

INTERVENTION(S):

Intensification of chelation therapy.

MAIN OUTCOME MEASURE(S):

Clinical evaluation, serum ferritin concentration, and biochemical assessment of pituitary function were performed periodically.

RESULT(S):

One year after normalization of serum ferritin levels and transferrin saturation was achieved, he became eugonadal.

CONCLUSION(S):

We believe that hypogonadotropic hypogonadism in juvenile hemochromatosis may be reversible by a consequent venesection therapy probably because treatment was intensive and promptly introduced at a young age.

[Indexed for MEDLINE]

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