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Eur J Cancer. 2006 Mar;42(4):528-33. Epub 2005 Dec 15.

Methylenetetrahydrofolate reductase 677C>T polymorphism and gastric cancer susceptibility in Mexico.

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Center for Population Health Research, National Institute of Public Health, Av. Universidad No. 655, Col. Santa Ma. Ahuacatitlán, 62508 Cuernavaca, Morelos, Mexico.


This study investigated whether methylenetetrahydrofolate reductase MTHFR 677C>T polymorphism modified gastric cancer (GC) risk independently as well as in combination with folate intake and alcohol consumption. A hospital-based case-control study of 201 cases and 427 controls was conducted in three geographical areas of Mexico, between 1994 and 1996. The MTHFR 677T allele frequency was 51.0% in cases compared with 45.3% in controls. After controlling for dietary sources of folate, alcohol intake and other selected variables, a significant increase in GC risk was found among carriers of the 677TT genotype compared with those with the 677CC genotype (odds ratio (OR) 1.62, 95% confidence interval (CI) 1.00-2.59), with a significant trend (P = 0.048). There were no significant interactions between the MTHFR polymorphism and consumption of folate and alcohol. Our results suggest that the high prevalence of MTHFR 677T allele may be a contributor to the high rate of morbidity and mortality in GC in Mexico.

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