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Eur J Cancer. 2006 Mar;42(4):528-33. Epub 2005 Dec 15.

Methylenetetrahydrofolate reductase 677C>T polymorphism and gastric cancer susceptibility in Mexico.

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1
Center for Population Health Research, National Institute of Public Health, Av. Universidad No. 655, Col. Santa Ma. Ahuacatitlán, 62508 Cuernavaca, Morelos, Mexico.

Abstract

This study investigated whether methylenetetrahydrofolate reductase MTHFR 677C>T polymorphism modified gastric cancer (GC) risk independently as well as in combination with folate intake and alcohol consumption. A hospital-based case-control study of 201 cases and 427 controls was conducted in three geographical areas of Mexico, between 1994 and 1996. The MTHFR 677T allele frequency was 51.0% in cases compared with 45.3% in controls. After controlling for dietary sources of folate, alcohol intake and other selected variables, a significant increase in GC risk was found among carriers of the 677TT genotype compared with those with the 677CC genotype (odds ratio (OR) 1.62, 95% confidence interval (CI) 1.00-2.59), with a significant trend (P = 0.048). There were no significant interactions between the MTHFR polymorphism and consumption of folate and alcohol. Our results suggest that the high prevalence of MTHFR 677T allele may be a contributor to the high rate of morbidity and mortality in GC in Mexico.

PMID:
16359859
DOI:
10.1016/j.ejca.2005.10.020
[Indexed for MEDLINE]

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