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Curr Opin Genet Dev. 2006 Feb;16(1):10-6. Epub 2005 Dec 15.

Drosophila models for cancer research.

Author information

1
Department of Molecular Biology and Pharmacology, Washington University School of Medicine, 660 South Euclid Avenue, Saint Louis, MO 63110, USA.

Abstract

Drosophila is a model system for cancer research. Investigation with fruit flies has facilitated a number of important recent discoveries in the field: the hippo signaling pathway, which coordinates cell proliferation and death to achieve normal tissue size; 'social' behaviors of cells, including cell competition and apoptosis-induced compensatory proliferation, that help ensure normal tissue size; and a growing understanding of how oncogenes and tumor suppressors cooperate to achieve tumor growth and metastasis in situ. In the future, Drosophila models can be extended beyond basic research in the search for human therapeutics.

PMID:
16359857
DOI:
10.1016/j.gde.2005.12.004
[Indexed for MEDLINE]

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