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Expert Rev Mol Diagn. 2006 Jan;6(1):39-50.

Advancement in characterization of genomic alterations for improved diagnosis, treatment and prognostics in cancer.

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1
Dental Research Institute, School of Dentistry & Jonsson Comprehensive Cancer Center, University of California at Los Angeles, Los Angeles, CA, USA. xfzhou@ucla.edu

Abstract

Most human cancers are characterized by genetic instabilities. These instabilities manifest themselves as a series of genetic alterations, including discrete mutations and chromosomal aberrations. With the human genome deciphered, high-throughput technologies are rapidly advancing the field to generate genome-wide gene expression and mutation profiles that are highly correlative of biologic and disease phenotypes. While recent advancement in comprehensive genomic characterization presents an unprecedented opportunity for advancing the treatment of cancer, there are still many challenges that need to be overcome before we can fully utilize genomic markers and targets for cancer prediction, diagnostics, treatment and prognostics. This review describes recent advances in comprehensive genomic characterization at the DNA level, and considers some of the challenges that remain for defining the precise genomic portrait of tumors. Potential solutions that may help overcome these challenges are also offered.

PMID:
16359266
DOI:
10.1586/14737159.6.1.39
[Indexed for MEDLINE]
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