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Psychiatr Pol. 2005 Sep-Oct;39(5):911-20.

[The role of copper and magnesium in the pathogenesis and treatment of affective disorders].

[Article in Polish]

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Klinika Psychiatrii Dorosłych CM UJ.


Magnesium and copper are important modulators of NMDA-receptor activity. Recent data indicate that disturbances of glutamatergic transmission (especially via NMDA-receptor) are involved in pathogenesis of mood disorders. Magnesium deficiency, the same as disturbances in turn over of copper, are related to a variety of psychological symptoms especially depression. There are many reports indicating significant changes in blood levels of magnesium or copper during a depressive episode. Moreover magnesium exhibits antidepressant-like and anxiolytic-like effects in animal models of depression, in rodents. This article reviews the alterations in central and peripheral magnesium and copper homeostasis in relation to pathophysiology and treatment of depression.

[Indexed for MEDLINE]

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