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Nat Rev Microbiol. 2006 Jan;4(1):67-76.

Virus membrane-fusion proteins: more than one way to make a hairpin.

Author information

1
Department of Cell Biology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, New York 10461, USA. kielian@aecom.yu.edu

Abstract

Structure-function studies have defined two classes of viral membrane-fusion proteins that have radically different architectures but adopt a similar overall 'hairpin' conformation to induce fusion of the viral and cellular membranes and therefore initiate infection. In both classes, the hairpin conformation is achieved after a conformational change is triggered by interaction with the target cell. This review will focus in particular on the properties of the more recently described class II proteins.

PMID:
16357862
DOI:
10.1038/nrmicro1326
[Indexed for MEDLINE]
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