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Cancer Lett. 2006 Jan 8;231(1):74-86.

A cDNA-microarray analysis of camptothecin resistance in glioblastoma cell lines.

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Fenice Environmental Research Center, Via Ciro Menotti 48, 48023 Marina di Ravenna, Ravenna, Italy.


Chemotherapy, as generally available, is of a limited value in curing malignant brain tumors (gliomas), which often develop resistance to drugs, becoming completely unresponsive to any standard therapeutic approach. Camptothecins, a family of topoisomerase I inhibitor drugs, represent a new promising treatment strategy and are currently under evaluation for testing the clinical efficacy. We selected a CPT-resistant sub-line (U87CPT-R) from U87-MG grade III-IV astrocytoma cells, and compared the expression profile of the two cell lines by cDNA-microarray, as a preliminary screening of the molecular mechanisms involved in the acquisition of CPT resistance in glioma cells. The relevant role of IL-1 beta overproduction as well as a generalised up-regulation of genes implicated in angiogenesis and inflammatory response are discussed in details.

[Indexed for MEDLINE]

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