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Trends Biochem Sci. 2006 Jan;31(1):13-6. Epub 2005 Dec 13.

Chutes and Ladders: the search for protein kinases that act on AMPK.

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1
Departments of Medicine and Biochemistry, Dartmouth Medical School and the Department of Biological Sciences, Dartmouth College, Hanover, NH 03755, USA. lee.a.witters@dartmouth.edu

Abstract

AMP-activated protein kinase (AMPK), a key regulator of energy homeostasis in mammalian cells, is, in turn, regulated by long-sought upstream protein kinases (AMPKKs). Following the recent identification of the tumor-suppressor kinase LKB1 as an AMPKK, a broader role for AMPK in metabolic economy has been unveiled by a new body of work from three groups that implicates the Ca(2+)/calmodulin-dependent protein kinase kinases as AMPKKs. We suggest that PKE (protein kinase "energy" or "economy") is now an apt name for this kinase, which regulates both cellular and whole-organism energy homeostasis.

PMID:
16356723
DOI:
10.1016/j.tibs.2005.11.009
[Indexed for MEDLINE]
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