Spontaneous liver hemorrhage during laparotomy for necrotizing enterocolitis: a potential role for recombinant factor VIIa

J Pediatr. 2005 Dec;147(6):857-9. doi: 10.1016/j.jpeds.2005.07.034.

Abstract

Necrotizing enterocolitis remains a serious condition in very low birth weight infants, particularly in those infants who require surgery. Perioperative hemorrhage is a potentially fatal complication in this population. We describe our experience in 4 premature infants with necrotizing enterocolitis who received recombinant factor VIIa to manage life-threatening intraoperative hemorrhage.

Publication types

  • Case Reports
  • Research Support, N.I.H., Extramural

MeSH terms

  • Enterocolitis, Necrotizing / surgery*
  • Factor VIIa / therapeutic use*
  • Hemorrhage / drug therapy*
  • Humans
  • Infant
  • Infant, Newborn
  • Infant, Premature*
  • Infant, Very Low Birth Weight*
  • Intraoperative Complications / drug therapy*
  • Laparotomy
  • Liver Diseases / drug therapy*
  • Recombinant Proteins / therapeutic use*
  • Rupture, Spontaneous
  • Treatment Outcome

Substances

  • Recombinant Proteins
  • Factor VIIa