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Clin Infect Dis. 2006 Jan 15;42(2):170-8. Epub 2005 Dec 13.

Control and outcome of a large outbreak of colonization and infection with glycopeptide-intermediate Staphylococcus aureus in an intensive care unit.

Author information

1
Medical-Surgical Intensive Care Unit, Louis-Mourier Teaching Hospital, Assistance Publique-Hôpitaux de Paris, Colombes, France. arnaud.de-lassence@lmr.ap-hop-paris.fr

Abstract

BACKGROUND:

Glycopeptide-intermediate Staphylococcus aureus (GISA) is emerging as a cause of nosocomial infection and outbreaks of infection and colonization in intensive care units (ICUs). We describe an outbreak of GISA colonization/infection and the ensuing control measures in an ICU and investigate outcomes of the affected patients.

METHODS:

We describe an outbreak of GISA colonization and infection that affected 21 patients in a medical ICU at a tertiary care teaching hospital, as well as the measures taken to eradicate the GISA strain.

RESULT:

Recognition of the outbreak was difficult. Infections, all of which were severe, were diagnosed in 11 of 21 patients. Patient isolation and barrier precautions failed when used alone. Addition of a stringent policy of restricted admissions, twice daily environmental cleaning, and implementation of hand decontamination with a hydroalcoholic solution led to outbreak termination. This was associated with increases in workload, despite a marked decrease in the number of admissions.

CONCLUSION:

This first description of a large outbreak of GISA colonization and infection underlines the importance of routine GISA-strain detection when methicillin-resistant S. aureus is isolated. Outbreak control may be difficult to achieve.

Comment in

PMID:
16355325
DOI:
10.1086/498898
[Indexed for MEDLINE]

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