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Nature. 2005 Dec 15;438(7070):967-74.

Angiogenesis as a therapeutic target.

Author information

1
Genentech, 1 DNA Way, South San Francisco, California 94080, USA. nf@gene.com

Abstract

Inhibiting angiogenesis is a promising strategy for treatment of cancer and several other disorders, including age-related macular degeneration. Major progress towards a treatment has been achieved over the past few years, and the first antiangiogenic agents have been recently approved for use in several countries. Therapeutic angiogenesis (promoting new vessel growth to treat ischaemic disorders) is an exciting frontier of cardiovascular medicine, but further understanding of the mechanisms of vascular morphogenesis is needed first.

PMID:
16355214
DOI:
10.1038/nature04483
[Indexed for MEDLINE]

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