Format

Send to

Choose Destination
AAPS J. 2005 Oct 19;7(3):E587-91.

Mu opioid receptor regulation and opiate responsiveness.

Author information

1
Department of Pharmacology, The Ohio State University College of Medicine and Public Health, Columbus, OH 43210, USA.

Abstract

Opiate drugs such as morphine are well known for their ability to produce potent analgesia as well as such unwanted side effects as tolerance, physical dependence, respiratory suppression and constipation. Opiates act at opioid receptors, which belong to the family of G protein-coupled receptors. The mechanisms governing mu opioid receptor (muOR) regulation are of particular interest since morphine and other clinically important analgesics produce their pharmacological effects through this receptor. Here we review recent advances in understanding how opioid receptor regulation can impart differential agonist efficacy produced in vivo.

PMID:
16353937
PMCID:
PMC2751262
DOI:
10.1208/aapsj070360
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Springer Icon for PubMed Central
Loading ...
Support Center