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Int J Antimicrob Agents. 2006 Jan;27(1):77-80. Epub 2005 Dec 13.

Transferable DHA-1 cephalosporinase in Escherichia coli.

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1
Department of Microbiology, National School of Public Health, Athens, Greece.

Abstract

Three Escherichia coli isolates resistant to third-generation cephalosporins but negative for extended-spectrum beta-lactamase production were isolated from hospitalised patients in Zagreb, Croatia, during June 2003 to February 2004. Resistance was due to the inducible production of a DHA-1 cephalosporinase. Each isolate contained an integron-associated bla(DHA-1)-ampR sequence carried by similar-sized plasmids, of which one was self-transferable. Serotyping and polymerase chain reaction typing using ERIC2 primer indicated that the isolates were distinct. This is the first description of DHA beta-lactamase production in E. coli.

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