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Science. 1975 Mar 28;187(4182):1206-8.

Insulin-induced augmentation of lymphocyte-mediated cytotoxicity.

Abstract

Physiologic concentrations of insulin enhance the ability of cytotoxic lymphocytes to injure target cells. The effect of insulin closely resembles the action of cholinomimetics and guanosine 3',5'-monophosphate upon this system. Since both insulin and cholinomimetics elevate intracellular concentrations of guanosine 3',5'-monophosphate, a common mode of action is suggested.

PMID:
163492
[Indexed for MEDLINE]
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