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Neurology. 2005 Dec 13;65(11):1817-9.

Comparison of family histories in FTLD subtypes and related tauopathies.

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  • 1Memory and Aging Center, University of California, San Francisco, CA 94117, USA.


Pedigrees from 269 patients with frontotemporal lobar degeneration (FTLD), including frontotemporal dementia (FTD), FTD with ALS (FTD/ALS), progressive nonfluent aphasia, semantic dementia (SD), corticobasal degeneration, and progressive supranuclear palsy were analyzed to determine the degree of heritability of these disorders. FTD/ALS was the most and SD the least heritable subtype. FTLD syndromes appear to have different etiologies and recurrence risks.

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