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Curr Opin Immunol. 2006 Feb;18(1):54-60. Epub 2005 Dec 15.

Systems biology of neutrophil differentiation and immune response.

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The Granulocyte Research Laboratory, Department of Hematology-9322, Rigshospitalet, University of Copenhagen, Juliane Mariesvej 20, 2100 Copenhagen-Ø, Denmark.


Systems biology has emerged as a new scientific field, which aims at investigating biological processes at the genomic and proteomic levels. Recent studies have unravelled aspects of neutrophil differentiation and immune responses at the systems level using high-throughput technologies. These studies have identified a plethora of novel effector proteins stored in the granules of neutrophils. In addition, these studies provide evidence that neutrophil differentiation and immune response are governed by a highly coordinated transcriptional programme that regulates cellular fate and function in a context-dependent manner.

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