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Psychiatry Res. 2006 Jan 30;146(1):87-90. Epub 2005 Dec 15.

Striatal dopamine D2/D3 receptor availability in male smokers.

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Department of Psychiatry, College of Medicine, National Cheng Kung University, 138, Sheng Li Road, Tainan 704, Taiwan.


It has been reported that the activation of the nicotine receptor evokes central endogenous dopamine release. However, whether smoking affects striatal dopamine D(2)/D(3) availability over the long run has not been well established in vivo. Fifteen male smokers and their matching controls were recruited. Striatal dopamine D(2)/D(3) receptor availability was assessed by single photon emission computed tomography with [(123)]IBZM Iodo-benzaimide. There was no significant difference in striatal D(2)/D(3) receptor availability between smokers and controls.

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