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Nat Rev Immunol. 2006 Jan;6(1):33-43.

Dectin-1: a signalling non-TLR pattern-recognition receptor.

Author information

1
Institute of Infectious Disease and Molecular Medicine, CLS, Faculty of Health Sciences, University of Cape Town, Observatory, Cape Town, 7925, South Africa. gordon.brown@mweb.co.za

Abstract

Dectin-1 is a natural killer (NK)-cell-receptor-like C-type lectin that is thought to be involved in innate immune responses to fungal pathogens. This transmembrane signalling receptor mediates various cellular functions, from fungal binding, uptake and killing, to inducing the production of cytokines and chemokines. These activities could influence the resultant immune response and can, in certain circumstances, lead to autoimmunity and disease. As I discuss here, understanding the molecular mechanisms behind these functions has revealed new concepts, including collaborative signalling with the Toll-like receptors (TLRs) and the use of spleen tyrosine kinase (SYK), that have implications for the role of other non-TLR pattern-recognition receptors in immunity.

PMID:
16341139
DOI:
10.1038/nri1745
[Indexed for MEDLINE]

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