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Nat Rev Mol Cell Biol. 2005 Dec;6(12):954-64.

Arp2/3 and SCAR: plants move to the fore.

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The Integrative Cell Biology Laboratory, School of Biological and Biomedical Sciences, University of Durham, South Road, Durham, DH1 3LE, UK.


The actin-nucleating Arp2/3 complex is essential for life in yeast and animals, but not in plants, in which mutants of Arp2/3 complex components show relatively minor developmental abnormalities. Animal cells control the activity of the Arp2/3 complex through the suppressor of cyclic AMP receptor (SCAR) complex to achieve cell motility. Amazingly, plants have also retained the SCAR cell-motility pathway, and now provide a unique model for the study of new aspects of SCAR function in the absence of cell motility.

[Indexed for MEDLINE]

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