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Nat Rev Mol Cell Biol. 2005 Dec;6(12):929-42.

Kinetochore capture and bi-orientation on the mitotic spindle.

Author information

1
School of Life Sciences, University of Dundee, Wellcome Trust Biocentre, Dow Street, Dundee, DD1 5EH, UK. t.tanaka@dundee.ac.uk

Abstract

Kinetochores are large protein complexes that are formed on chromosome regions known as centromeres. For high-fidelity chromosome segregation, kinetochores must be correctly captured on the mitotic spindle before anaphase onset. During prometaphase, kinetochores are initially captured by a single microtubule that extends from a spindle pole and are then transported poleward along the microtubule. Subsequently, microtubules that extend from the other spindle pole also interact with kinetochores and, eventually, each sister kinetochore attaches to microtubules that extend from opposite poles - this is known as bi-orientation. Here we discuss the molecular mechanisms of these processes, by focusing on budding yeast and drawing comparisons with other organisms.

PMID:
16341079
DOI:
10.1038/nrm1764
[Indexed for MEDLINE]
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