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Nat Rev Drug Discov. 2005 Dec;4(12):977-87.

Anti-inflammatory effects of statins: clinical evidence and basic mechanisms.

Author information

1
Program in Cardiovascular Transcriptional Biology, Cardiovascular Division, Brigham and Womens Hospital, Harvard Medical School, 75 Francis Street, Boston, Massachusetts 02115, USA.

Abstract

Chronic inflammation is a key feature of vascular disease states such as atherosclerosis. Multiple clinical studies have shown that a class of medications termed statins lower cardiovascular morbidity and mortality. Originally developed to lower serum cholesterol, increasing evidence suggests that these medications have potent anti-inflammatory effects that contribute to their beneficial effects in patients. Here, we discuss the clinical and experimental evidence underlying the anti-inflammatory effects of these agents.

PMID:
16341063
DOI:
10.1038/nrd1901
[Indexed for MEDLINE]

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