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Neuroscience. 2006 Apr 28;139(1):181-93. Epub 2005 Dec 5.

Brain mechanisms of proactive interference in working memory.

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Department of Psychology, University of Michigan, 525 East University, Ann Arbor, MI 48109-1109, USA.


It has long been known that storage of information in working memory suffers as a function of proactive interference. Here we review the results of experiments using approaches from cognitive neuroscience to reveal a pattern of brain activity that is a signature of proactive interference. Many of these results derive from a single paradigm that requires one to resolve interference from a previous experimental trial. The importance of activation in left inferior frontal cortex is shown repeatedly using this task and other tasks. We review a number of models that might account for the behavioral and imaging findings about proactive interference, raising questions about the adequacy of these models.

[Indexed for MEDLINE]

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