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Crit Rev Biotechnol. 1992;12(3):245-60.

ACV synthetase.

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1
Department of Biology, Massachusetts Institute of Technology, Cambridge 02139.

Abstract

ACV synthetase (ACVS) is the first enzyme and plays a key role in the biosynthesis of all natural penicillins and cephalosporins. The enzyme is extremely unstable and little had been known about it until recently. This article summarizes the progress in research on this enzyme, including the establishment of a cell-free assay system, stabilization, purification, characterization, and gene cloning. A possible reaction sequence for ACVS catalysis is suggested.

PMID:
1633622
DOI:
10.3109/07388559209069194
[Indexed for MEDLINE]
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