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Biol Chem. 2005 Dec;386(12):1273-7.

6S RNA - an ancient regulator of bacterial RNA polymerase rediscovered.

Author information

1
Institut für Pharmazeutische Chemie, Philipps-Universität Marburg, D-35037 Marburg, Germany. willkomm@staff.uni-marburg.de

Abstract

The bacterial riboregulator 6S RNA was one of the first non-coding RNAs to be discovered in the late 1960s, but its cellular role remained enigmatic until the year 2000. 6S RNA, only recognized to be ubiquitous among bacteria in 2005, binds to RNA polymerase in a sigma factor-dependent manner to repress transcription from a subgroup of promoters. The common feature of a double-stranded rod with a central bulge has led to the proposal that 6S RNA may mimic an open promoter complex.

PMID:
16336121
DOI:
10.1515/BC.2005.144
[Indexed for MEDLINE]

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