Format

Send to

Choose Destination
See comment in PubMed Commons below
J Proteome Res. 2005 Nov-Dec;4(6):1961-71.

Principal component analysis of the conformational freedom within the EF-hand superfamily.

Author information

1
Department of Food Science, University of Bologna, 47023 Cesena, Italy.

Abstract

A database of nonredundant structures of EF-hand domains--i.e., pairs of helix-loop-helix motifs--has been assembled, and the six angles among the four helices re-determined. A principal component analysis of these angles allows us to use two such components (PC1 and PC2) to describe the system retaining 80% of the total variance. A PC2 against PC1 plot representation allows us to represent in a compact way the full range of structural diversity of EF-hand domains, their grouping into protein families, and the variation for each family upon calcium and peptide binding.

PMID:
16335940
DOI:
10.1021/pr050148n
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for American Chemical Society
    Loading ...
    Support Center