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Curr Opin Genet Dev. 1992 Feb;2(1):28-32.

Negative regulators of growth.

Author information

1
Howard Hughes Medical Institute, New York, New York.

Abstract

The proliferation of cells is regulated by countervailing positively- and negatively-acting signaling networks. The anti-proliferative signals, the study of which has been much neglected until recently, are often conveyed by growth-inhibitory peptides. Elements that mediate the cellular response to growth inhibitors are encoded by tumor suppressor genes that if lost may lead to the runaway growth of the cancer cell.

PMID:
1633423
DOI:
10.1016/s0959-437x(05)80317-x
[Indexed for MEDLINE]

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