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Biochem Cell Biol. 2005 Dec;83(6):752-61.

The organization, structure, and inheritance of the ER in higher and lower eukaryotes.

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Department of Cell Biology, Yale University School of Medicine, Boyer Center for Molecular Medicine, New Haven, CT 06519, USA.


The endoplasmic reticulum (ER) is a fundamental organelle required for protein assembly, lipid biosynthesis, and vesicular traffic, as well as calcium storage and the controlled release of calcium from the ER lumen into the cytosol. Membranes functionally linked to the ER by vesicle-mediated transport, such as the Golgi complex, endosomes, vacuoles-lysosomes, secretory vesicles, and the plasma membrane, originate largely from proteins and lipids synthesized in the ER. In this review we will discuss the structural organization of the ER and its inheritance.

[Indexed for MEDLINE]

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