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Arch Gen Psychiatry. 2005 Dec;62(12):1377-84.

Hostile marital interactions, proinflammatory cytokine production, and wound healing.

Author information

1
Department of Psychiatry, Institute for Behavioral Medicine Research, Ohio State University College of Medicine, 1670 Upham Drive, Columbus, OH 43210, USA. kiecolt-glaser.1@osu.edu

Abstract

CONTEXT:

A growing epidemiological literature has suggested that marital discord is a risk factor for morbidity and mortality. In addition, depression and stress are associated with enhanced production of proinflammatory cytokines that influence a spectrum of conditions associated with aging.

OBJECTIVE:

To assess how hostile marital behaviors modulate wound healing, as well as local and systemic proinflammatory cytokine production.

DESIGN AND SETTING:

Couples were admitted twice to a hospital research unit for 24 hours in a crossover trial. Wound healing was assessed daily following research unit discharge.

PARTICIPANTS:

Volunteer sample of 42 healthy married couples, aged 22 to 77 years (mean [SD], 37.04 [13.05]), married a mean (SD) of 12.55 (11.01) years.

INTERVENTIONS:

During the first research unit admission, couples had a structured social support interaction, and during the second admission, they discussed a marital disagreement.

MAIN OUTCOME MEASURES:

Couples' interpersonal behavior, wound healing, and local and systemic changes in proinflammatory cytokine production were assessed during each research unit admission.

RESULTS:

Couples' blister wounds healed more slowly and local cytokine production (IL-6, tumor necrosis factor alpha, and IL-1beta) was lower at wound sites following marital conflicts than after social support interactions. Couples who demonstrated consistently higher levels of hostile behaviors across both their interactions healed at 60% of the rate of low-hostile couples. High-hostile couples also produced relatively larger increases in plasma IL-6 and tumor necrosis factor alpha values the morning after a conflict than after a social support interaction compared with low-hostile couples.

CONCLUSIONS:

These data provide further mechanistic evidence of the sensitivity of wound healing to everyday stressors. Moreover, more frequent and amplified increases in proinflammatory cytokine levels could accelerate a range of age-related diseases. Thus, these data also provide a window on the pathways through which hostile or abrasive relationships affect physiological functioning and health.

PMID:
16330726
DOI:
10.1001/archpsyc.62.12.1377
[Indexed for MEDLINE]

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