Format

Send to

Choose Destination
Nat Biotechnol. 2006 Jan;24(1):73-5. Epub 2005 Dec 4.

Conservation of gene expression signatures between zebrafish and human liver tumors and tumor progression.

Author information

1
Department of Biological Sciences, 14 Science Drive 4, National University of Singapore, Singapore 117543.

Abstract

The zebrafish (Danio rerio) has been long advocated as a model for cancer research, but little is known about the real molecular similarities between zebrafish and human tumors. Comparative analysis of microarray data from zebrafish liver tumors with those from four human tumor types revealed molecular conservation at various levels between fish and human tumors. This approach provides a useful strategy for identifying an expression signature that is strongly associated with a disease phenotype.

Comment in

PMID:
16327811
DOI:
10.1038/nbt1169
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Nature Publishing Group
Loading ...
Support Center