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Nat Rev Cancer. 2005 Nov;5(11):867-75.

Radiation and the microenvironment - tumorigenesis and therapy.

Author information

1
Life Sciences Division, Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Berkeley, California 94720, USA. mhbarcellos-hoff@lbl.gov

Abstract

Radiation rapidly and persistently alters the soluble and insoluble components of the tissue microenvironment. This affects the cell phenotype, tissue composition and the physical interactions and signalling between cells. These alterations in the microenvironment can contribute to carcinogenesis and alter the tissue response to anticancer therapy. Examples of these responses and their implications are discussed with a view to therapeutic intervention.

PMID:
16327765
DOI:
10.1038/nrc1735
[Indexed for MEDLINE]

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