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Asia Pac J Clin Nutr. 2005;14(4):307-12.

Antiarrhythmic effects of n-3 polyunsaturated fatty acids.

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Cardiac ElectrophysiologyResearch and Training Center, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.


The n-3 or omega 3 polyunsaturated fatty acids are a promising dietary preventive therapy for cardiovascular disease. The main dietary source of n-3 polyunsaturated fatty acids comes from sea fish. During recent years, the subject of antiarrhythmic role of n-3 polyunsaturated fatty acids has been investigated extensively. A great deal of evidence has shown that the antiarrhythmic effect of n-3 polyunsaturated fatty acids is exerted by altering the electrophysiology of myocytes. This article is intended to review specifically this role of n-3 polyunsaturated fatty acids as demonstrated by both basic and clinical evidence in animal and human studies, including current concepts on the antiarrhythmic mechanism of this class of polyunsaturated fatty acids.

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