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Bioorg Med Chem Lett. 2006 Feb;16(3):618-21. Epub 2005 Dec 1.

The design and synthesis of YC-1 analogues as probes for soluble guanylate cyclase.

Author information

1
Department of Chemistry, University of Michigan, Ann Arbor, MI 48109-1055, USA.

Abstract

Soluble guanylate cyclase (sGC) is highly activated in the presence of both YC-1 (1-benzyl-3-(5'-hydroxymethyl-2'-furyl)-indazole) and CO. In this report, the design, synthesis, and activity (i.e., sGC activation) of photolabile analogues of 3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole (YC-1) are presented. Initial results with 6-azido-3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole led to the synthesis of a tritium-labeled analogue. When photoactivated, this analogue labeled the alpha-subunit of sGC.

PMID:
16326101
DOI:
10.1016/j.bmcl.2005.10.093
[Indexed for MEDLINE]

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