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Cell. 2005 Dec 2;123(5):757-60.

The battlefield of pluripotency.

Author information

1
Centre Development in Stem Cell Biology, Institute for Stem Cell Research, School of Biological Sciences, University of Edinburgh, King's Buildings, West Mains Road, Edinburgh EH9 3JQ, United Kingdom. austin.smith@ed.ac.uk

Abstract

How embryonic stem cells maintain the potential to differentiate into multiple cell lineages is still unclear. In this issue of Cell, Niwa et al. (2005) show that a duel between the transcription factors Oct3/4 and Cdx2 can restrict embryonic stem cells to either embryonic or placental fate. The vulnerability of lineage potential to transcriptional perturbation may reflect an essential feature of pluripotency.

PMID:
16325569
DOI:
10.1016/j.cell.2005.11.012
[Indexed for MEDLINE]
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