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Cell. 2005 Dec 2;123(5):755-7.

Beta-arrestin goes nuclear.

Author information

1
Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA.

Abstract

Arrestins have important roles in the cytoplasm and at the plasma membrane, including the desensitization and internalization of G protein-coupled receptors (GPCRs). In this issue of Cell, Kang et al. (2005) provide evidence that beta-arrestin 1 moves to the nucleus in response to GPCR stimulation, where it regulates gene expression by facilitating histone acetylation at specific gene promoters.

PMID:
16325568
DOI:
10.1016/j.cell.2005.11.010
[Indexed for MEDLINE]
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