Format

Send to

Choose Destination
See comment in PubMed Commons below
J Infect Dis. 2006 Jan 1;193(1):45-8. Epub 2005 Nov 21.

Disproportionately high semen shedding of HIV is associated with compartmentalized cytomegalovirus reactivation.

Author information

  • 1Department of Medicine, University of Toronto, Mount Sinai Hospital, Canada.

Abstract

Semen transmission of human immunodeficiency virus (HIV) drives the global pandemic. HIV loads are generally lower in semen than in blood, but semen loads may be disproportionately high in a subgroup of men. HIV loads in semen exceeded those in blood in 9 (35%) of 26 of antiretroviral therapy-naive men, and disproportionately high shedding was strongly associated with compartmentalized semen cytomegalovirus (CMV) reactivation (odds ratio [OR], 10.5; P<.01). Overall, 17 of 26 participants were shedding CMV in semen. Semen levels of HIV and CMV were closely correlated (r=0.5; P<.01), independently of blood HIV load and CD4(+) T cell count. Prevention of CMV reactivation warrants further study as a possible strategy to reduce semen shedding of HIV.

PMID:
16323130
DOI:
10.1086/498576
[PubMed - indexed for MEDLINE]
Free full text
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for HighWire
    Loading ...
    Support Center